Using Breast Milk to Screen for Breast Cancer and Assess Breast Cancer Risk
The purpose of this study is to determine if breast cancer and breast cancer risk can be accurately assessed from a breast milk sample. Currently, there is no accurate way to give women information about their personal risk of developing breast cancer. We will use the cells naturally present in breast milk to examine changes in DNA that occur in association with benign and cancerous breast lesions. Learning about the genetic changes associated with both breast cancer and non-cancerous breast lesions will help us develop a way to provide women with information about their breast cancer risk. Using breast milk to screen for breast cancer will reduce unnecessary biopsies among nursing women.
This research is made possible by a grant from the U.S. Department of Defense Breast Cancer Research Program.
Breast Milk and Breast Milk Cells: Biomarkers of Exposure, Effect and Genetic Susceptibility to Breast Cancer
Breast milk is an ideal human fluid for studying the relationship between exposure to pollutants and breast cancer risk because it contains lipophilic compounds implicated in the etiology of breast cancer and exfoliated breast epithelial cells. We have ongoing studies in which we are analyzing the relationship between pollutants in milk and levels of DNA damage, changes in gene expression and promoter hypermethylation in the exfoliated breast epithelial cells.
This research is made possible by a grant from the Avon Foundation.